書籍

• Tang CK, Coban C, Akira S, Ishii KJ. Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology. Chapter 1: Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic DNA sensing. Elsevier. 2013
• Coban C, Tozuka M, Jounai N, Kobiyama K, Takeshita F, Tang CK, Ishii KJ. Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology. Chapter 11: DNA vaccines: Common way of DNA sensing? Elsevier. 2013

雑誌

• Ito H, Ando T, Ito H, Ando T, Nakamura M, Ishida H, Kanbe A, Kobiyama K, Yamamoto T, Ishii KJ, Hara A, Seishima M, Ishikawa T.Induction of humoral and cellular immune response to hepatitis B virus (HBV) vaccine can be upregulated by CpG oligonucleotides complexed with Dectin-1 ligand.J Viral Hepat. 2016
• Yokokawa H, Higashino A, Suzuki S, Moriyama M, Nakamura N, Suzuki T, Suzuki R, Ishii K, Kobiyama K, Ishii KJ, Wakita T, Akari H, Kato T.Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model.Gut. 2016
• Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ.Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells.Oncotarget. 2016
• Hayashi M, Aoshi T, Ozasa K, Kusakabe T, Momota M, Haseda Y, Kobari S, Kuroda E, Kobiyama K, Coban C, Ishii KJ.RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.Sci Rep. 2016
• Tsuchiya Y, Jounai N, Takeshita F, Ishii KJ, Mizuguchi K.Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1.EBioMedicine. 2016
• Hirai T, Yoshioka Y, Izumi N, Ichihashi KI, Handa T, Nishijima N, Uemura E, Sagami KI, Takahashi H, Yamaguchi M, Nagano K, Mukai Y, Kamada H, Tsunoda SI,Ishii KJ, Higashisaka K, Tsutsumi Y.Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice.Nat Nanotechnol. 2016
• Shiraishi K, Kawano K, Maitani Y, Aoshi T, Ishii KJ, Sanada Y, Mochizuki S, Sakurai K, Yokoyama M.Exploring the relationship between Anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance.J Control Release. 2016
• Kusakabe T, Ozasa K, Kobari S, Momota M, Kishishita N, Kobiyama K, Kuroda E, Ishii KJ.Intranasal hydroxypropyl-β-cyclodextrin-adjuvanted influenza vaccine protects against sub-heterologous virus infection.Vaccine. 2016
• Temizoz B, Kuroda E, Ishii KJ.Vaccine adjuvants as potential cancer immunotherapeutics.Int Immunol. 2016
• Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.Sci Rep. 2016
• Lee MS, Igari Y, Tsukui T, Ishii KJ, Coban C.Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation.Vaccine. 2016
• Hirai T, Yoshioka Y, Takahashi H, Handa T, Izumi N, Mori T, Uemura E, Nishijima N, Sagami KI, Yamaguchi M, Eto SI, Nagano K, Kamada H, Tsunoda SI, Ishii KJ, Higashisaka K, Tsutsumi Y.High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis.Clin Exp Allergy. 2016
• Kohyama M, Matsuoka S, Shida K, Sugihara F, Aoshi T, Kishida K, Ishii KJ, Arase H.Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.Eur J Immunol. 2016
• Kobiyama K, Temizoz B, Kanuma T, Ozasa K, Momota M, Yamamoto T, Aoshi T, Kuroda E, Ishii KJ.Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan.Eur J Immunol. 2016
• MaruYama T, Sayama A, Ishii KJ, Muta T.Screening of posttranscriptional regulatory molecules of IκB-ζ. Biochem Biophys Res Commun. 2016
• Guidance Development Review Committee; Working Group for Clinical Studies of Cancer Immunotherapy; Working Group for Effector Cell Therapy; Working Group for CMC/Non-clinical Studies; Working Group for Cancer Vaccines and Adjuvants; Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer Immunotherapy; Biostatistics Subcommittee.2015 Guidance on cancer immunotherapy development in early-phase clinical studies.Cancer Sci. 2015 Dec;106(12):1761-71.
• Tozuka M, Oka T, Jounai N, Egawa G, Ishii KJ, Kabashima K, Takeshita F. Efficient antigen delivery to the draining lymph nodes is a key component in the immunogenic pathway of the intradermal vaccine.J Dermatol Sci. pii: S0923-1811(15) 30079-7 2015
• Hayashi M, Aoshi T, Kogai Y, Nomi D, Haseda Y, Kuroda E, Kobiyama K, Ishii KJ Optimization of physiological properties of hydroxyapatite as a vaccine adjuvant.Vaccine. pii: S0264-410X(15) 01725-9 2015
• Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis.Sci Rep. 5 18174 2015
• Mochizuki S, Morishita H,Kobiyama K, Aoshi T, Ishii KJ, Sakurai K. Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs.J Control Release. S0168-3659(15) 30232-7 2015
• Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, Enomoto T, Kimura T, Naka T.CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody. Cancer Sci. 106(10) 1474-8 2015
• Tsuzuki S, Tachibana M, Hemmi M, Yamaguchi T, Shoji M, Sakurai F, Kobiyama K, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector. Int Immunol. 2015
• Kobiyama K, Ishii KJ. Development of Nucleic Acid-Based Adjuvant for Cancer Immunotherapy.Gan To Kagaku Ryoho. 42(9) 1040-5 2015
• Halder SK, Matsunaga H, Ishii KJ, Ueda H. Prothymosin-alpha preconditioning activates TLR4-TRIF signaling to induce protection of ischemic retina. J Neurochem. 2015
• Hirai T, Yoshioka Y, Takahashi H, Ichihashi K, Udaka A, Mori T, Nishijima N, Yoshida T, Nagano K, Kamada H, Tsunoda S, Takagi T, Ishii KJ, Nabeshi H, Yoshikawa T, Higashisaka K, Tsutsumi Y. Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice. Part Fibre Toxicol. 2015
• Shen YJ, Le Bert N, Chitre AA, Koo CX, Nga XH, Ho SS, Khatoo M, Tan NY, Ishii KJ, Gasser S. Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells. Cell Rep. 2015
• Koo CX, Kobiyama K, Shen YJ, LeBert N, Ahmad S, Khatoo M, Aoshi T, Gasser S, Ishii KJ. RNA Polymerase III Regulates Cytosolic RNA:DNA Hybrids and Intracellular MicroRNA Expression. J Biol Chem. 2015
• Temizoz B, Kuroda E, Ohata K, Jonai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ. TLR9 and STING agonists synergistically induce innate and adaptive type II IFN. Eur J Immunol. 2014
• Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci USA. 111(8) 3086-91 2014
• Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y. Innate Immune response induced by baculovirus attenuates transgene expression in Mammalian cells. J Virol. 88(4) 2157-67 2014
• Kobiyama K, Jounai N, Aoshi T, Tozuka M, Takeshita F, Coban C and Ishii KJ. Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination Vaccines 1 278-292 2013
• Kuroda E, Coban C, Ishii KJ Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects. Int Rev Immunol 32(2) 209-20 2013
• Okubo S., Miyamoto M., Takami K., Kanki M., Ono A., Nakatsu N.,Yamada H., Ohno Y. and Urushidani T. Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds Toxicol. Sci. 132(1) 21-31 2013
• Nystrom-Persson J., Igarashi Y., Ito M., Morita M., Nakatsu N., Yamada H., Mizuguchi K. Toxygates: Interactive Toxicity Analysis on a Hybrid Microarray and Linked Data Platform Bioinformatics 29(23) 3080-3086 2013
• Uehara T., Horinouchi A., Morikawa Y., Tonomura Y., Minami K., Ono A., Yamate J., Yamada H., Ohno Y. and Urushidani T. Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats J. Appl. Toxicol. 2013
• Tripathi L. P., Kambara, H., Chen Y. A. , Nishimura Y., Moriishi, K., Okamoto T., Morita, E., Abe, T., Mori, Y., Matsuura, Y., Mizuguchi K. Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach Journal of Proteome Research 12(6) 2537-51 2013
• Fujita J., Miyazaki Y., Hirose M., Nagao C., Mizohata E., Matsumoto Y., Mizuguchi K., Inoue T., Matsumura H.
• Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 8) 895-8 2013
• Yoshimaru T., Komatsu M., Matsuo T., Chen Y. A., Murakami Y., Mizuguchi K., Mizohata E., Inoue T., Akiyama M., Yamaguchi R., Imoto S., Miyano S., Miyoshi Y., Sasa M., Nakamura Y., Katagiri T.　　
• Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells Nat Commun 4 2443 2013
• Andrabi M.,　Mizuguchi K.,　Ahmad S. Conformational changes in DNA-binding proteins: Relationships with precomplex features and contributions to specificity and stability Proteins In press 2014
• Nagao C., Nagano N., Mizuguchi K. Prediction of detailed enzyme functions and identification of specificity determining residues by random forests PLoS One 9(1) e84623 2014
• Sato, S., Kaneto, S., Shibata, N., Takahashi, Y., Kiyono, H,　 et al. Transcription factor Spi-B-dependent and -independent pathways for the development ofPeyer's patch M cells. Mucosal Immunol. 6 838-846 2013
• Kusu, T.,　 Kayama, H., Jeon, S-G., Ueda, Y., Kiyono, H. et al. ENTPDase7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J. Immunol. 190 774-783 2013
• Kunisawa, J.,　 Gohda, M., Hashimoto, E., Ishikawa, I., Kiyono, H, et al. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nature Commun. 4 1772 2013
• Onji, M., Kanno, A., Saitoh, S., Fukui, R., Kiyono, H. et al. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nature Commun. 4 1949 2013
• Kurokawa, S Nakamura, R., Mejima, M., Kozuka-Hata, H., Kiyono, H, at al. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of α-amylase/trypsin inhibitor-like protein family as major rice allergens. J. Proteome Res. 12 3372-3382 2013
• Tokuhara, D., Alvarez, B., Mejima, M., Hiroiwa, T., Kiyono, H, et al. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J. Clin. Invest. 123 3829-3838 2013
• Imai, T.,　 Koyanagi, N., Ogawa, R., Suenaga, T., Kiyono, H, et al. Us3 kinase encoded by herpes simplex virus 1 mediates Down regulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLos One 8 e72050 2013
• Yuki, Y., Mejima, M., Kurokawa, S., Hiroiwa, T., Kiyono, H, et al. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol. J. 11 799-808 2013
• Kishino, S., Takeuchi, M., Park, SB., Hirata, A., Kiyono, H, et al. Polyunsaturated fatty acid saturation by gut lactic acid bacteriaaffecting host lipid composition. Proc. Natl. Acad. Sci. USA. 110 17808-17813 2013
• Korneychuk N., Ramiro-Puig E, Ettersperger J, Schulthess J, Kiyono, H, et al. Interleukin 15 and CD4+ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology 146(4) 1017-1027 2013
• Kunisawa, J., and Kiyono, H. Vitamin-mediated regulation of intestinal immunity. Frontier in Immunol. 4 189 2013
• Kurashima Y., Goto Y., and Kiyono, H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur. J. Immunol. 43 3108-3115 2013
• Yuki, Y., Nochi, T., Kong, I.G., Takahashi, H., Kiyono, H, et al. Nanogel-based antigen-delivery system for nasal vaccines. Biotechnol. Genet. Eng. Rev. 29(1) 61-72 2013
• Kurokawa, S., Kuroda, M., Mejima, M., Nakamura, R., Kiyono, H, et al. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep. 33 75-87 2014
• Fujihashi, K., Sato S., and Kiyono, H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp. Gerontology in press 2014
• Kurashima, Y. and Kiyono, H. Skin-barrier homeostasis through Cyp26b1-mediated inhibition of ATP-dependent mast cell activation by fibroblasts. Immunity in press 2014
• Abe, M., Yuki, Y., Kurokawa, S., Mejima, M., Kuroda, Kiyono, H, et al. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J. Biotechnol. In press. 2014
• Matsumoto Makoto,Sasaki Yuki,Yasuda Koubun, Toshiyuki Takai, Masamichi Muramatsu, Yoshimoto Tomohiro,Nakanishi Kenji IgG and IgE collaboratively accelerate expulsion of Strongylodies Venezuelensis in a primary infection Infection and Immunity 81(7) 2518-2527 2013
• Fukuoka Ayumi,Futatsugi-Yumikura Shizue, Takahashi Suzuka,Kazama Hirotaka,Iyoda Tomonori,Yoshimoto Tomohiro, Inaba Kayo, Nakanishi Kenji, Yonehara Shin. Identification of a novel type 2 innate immunocyte with the ability to enhance IgE production International Immuology 25(6) 373--382 2013
• Takahashi Suzuka,Futatsugi-Yumikura Shizue,Fukuoka Ayumi, Yoshimoto Tomohiro, Nakanishi, Kenji, Yonehara Shin. Fas deficiency in mice with the Balb/c background induces vlepharitis with allergicinflammation and hyper-IgE prouction in conjunction with severe autoimmune disease International immunology 25(5) 287-293 2013
• Imai Yasutomo,Yasuda Koubun,Sakaguchi Yoshiko,Futatsugi-Yumikura Shizue, Yoshimoto Tomohiro, Nakanishi Kenji, Ymanishi Kiyofumi Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice Proceedings of the National Academy of Sciences of the United States of America 110(34) 13921-13926 2013
• Yasuda Koubun,Matsumoto Makoto, Nakanishi Kenji Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S.venezuelensis. Front Immunology 119(5) 118 2014
• Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T. IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection. J Immunol. in press 2014
• Tatematsu M, Seya T, Matsumoto M. Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses. Biochem J. 458(2) 195-201 2014
• Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T. MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells. Mol Immunol. 57(2) 100-110 2014
• Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F. Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc Natl Acad Sci U S A. 110(49) 19908-19913 2013
• Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T. The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. J Immunol. 191(9) 4740-4747 2013
• Oshiumi H, Miyashita M, Matsumoto M, Seya T. A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses. PLoS Pathog. 9(8) e1003533 2013
• Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H. Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. J Virol. 87(19) 10900-10903 2013
• Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K. Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells. J Virol. 87(14) 8169-8178 2013
• Tatematsu M, Nishikawa F, Seya T, Matsumoto M. Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA. Nat Commun. 4 1833 2013
• Seya T, Azuma M, Matsumoto M. Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer. Expert Opin Ther Targets. 17(5) 533-544 2013
• Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T. Multi-step regulation of interferon induction by hepatitis C virus. Arch Immunol Ther Exp (Warsz) 61(2) 127-138 2013
• Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S. Cleaved/associated TLR3 represents the primary form of the signaling receptor. J Immunol. 190(2) 764-773 2013
• Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 5 3492 2014
• Schulke,S., Wolfheimer,S., Gadermaier,G., Wangorsch,A., Siebeneicher,S., Briza,P., Spreitzer,I., Schiller,D., Loeschner,B., Uematsu,S., Ryffel,B., Akira,S., Waibler,Z., Vieths,S., Toda,M. and Scheurer,S. Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC. PLoS One. 9 e87822 2014
• Sugita,K., Ikenouchi-Sugita,A., Nakayama,Y., Yoshioka,H., Nomura,T., Sakabe,J., Nakahigashi,K., Kuroda,E., Uematsu,S., Nakamura,J., Akira,S., Nakamura,M., Narumiya,S., Miyachi,Y., Tokura,Y. and Kabashima,K. Prostaglandin E2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production. Sci Rep. 3 2973 2013
• Ogino,T., Nishimura,J., Barman,S., Kayama,H., Uematsu,S., Okuzaki,D., Osawa,H., Haraguchi,N., Uemura,M., Hata,T., Takemasa,I., Mizushima,T., Yamamoto,H., Takeda,K., Doki,Y. and Mori,M. Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease. Gastroenterology. 145 1380-1391 2013
• Maruyama,K., Uematsu,S., Kondo,T., Takeuchi,O., Martino,M.M., Kawasaki,T. and Akira,S. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med. 210 1947-1960 2013
• Nguyen,C.T., Hong,S.H., Sin,J.I., Vu,H.V., Jeong,K., Cho,K.O., Uematsu,S., Akira,S., Lee,S.E. and Rhee,J.H. Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model. Vaccine. 31 3879-3887 2013
• Kawashima,T., Kosaka,A., Yan,H., Guo,Z., Uchiyama,R., Fukui,R., Kaneko,D., Kumagai,Y., You,D.J., Carreras,J., Uematsu,S., Jang,M.H., Takeuchi,O., Kaisho,T., Akira,S., Miyake,K., Tsutsui,H., Saito,T., Nishimura,I. and Tsuji,N.M. Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity. 38 1187-1197 2013
• Fukasaka,M., Ori,D., Kawagoe,T., Uematsu,S., Maruyama,K., Okazaki,T., Kozaki,T., Imamura,T., Tartey,S., Mino,T., Satoh,T., Akira,S, and Takeuchi,O.. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J Immunol. 190 5702-5711 2013
• Kaiko,G.E., Loh,Z., Spann,K., Lynch,J.P., Lalwani,A., Zheng,Z., Davidson,S., Uematsu,S., Akira,S., Hayball,J., Diener,K.R., Baines,K.J., Simpson,J.L., Foster,P.S. and Phipps,S. Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. J Allergy Clin Immunol. 131 1331-1339 2013
• Akitake,Y., Nakatani,Y., Kamei,D., Hosokawa,M., Akatsu,H., Uematsu,S., Akira,S., Kudo,I., Hara,S. and Takahashi,M. Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model.. J Neurosci Res. 91 909-919 2013
• Watanabe K., Matsubara A, Kawano M, Mizuno S, Okamura T, Tsujimura Y, Inada H, Nosaka T, Matsuo K. and Yasutomi Y. Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization Vaccine 32 1727-1735 2014
• Wada T, Kohara M, Yasutomi Y. DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model. Vaccine 31 5968-5974 2013
• Kitagawa H, Kawano M, Yamanaka K, Kakeda M, Tsuda K, Inada H, Yoneda M, Sakaguchi T, Nigi A, Nishimura K, Komada H, Tsurudome M, Yasutomi Y, Nosaka T, Mizutani H. Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis. PLoS One 8 e66614 2013
• Shimozawa N, Ono R, Shimada M, Shibata H, Takahashi I, Inada H, Takada T, Nosaka T, Yasutomi Y Cynomolgus monkey induced pluripotent stem cells established by using exogenous genes derived from the same monkey species.
• Differentiation 85 131-139 2013
• Tajiri K, Shimojo N, Sakai S, Machino-Ohtsuka T, Imanaka-Yoshida K, Hiroe M, Tsujimura Y, Kimura T, Sato A, Yasutomi Y, Aonuma K. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 27 413-424 2013
• Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama EE, Akari H TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1 J Gen Virol. 94 1318-1324 2013
• Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H Dynamics of cellular immune responses in the acute phase of dengue virus infection. Arch Virol 158 1209-1220 2013
• Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T. TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Hum Vaccin Immunother. 9 283-290 2013
• Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi　A Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells. Microbes Infect. 5 56-65 2013
• Onishi M, Kuroda E, Kobiyama, K, Ozasa K, Kitano M, Taniguchi K, Homma T,Kobayashi M, 　Sato A, Katakai Y, Yasutomi Y, Wijaya E, Yoshinobu I, Noriyuki N, Hiroshi Y, Vandenbon A, Standley DM, 　Coban C, Aoshi T,and Ishii KJ. Re-positioning a common excipient Hydroxypropyl-beta-cyclodextrin into a potent influenza vaccine adjuvant by unique local innate immune mechanisms Science Translational Medicine 2014
• Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P,Hayashizaki Y, Forrest ARR, Standley DM, Date H, Sakaguchi S, and the FANTOM Consortium Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation Proc Natl Acad Sci 111(14) 5289-94 2014
• Uehata T, Iwasaki H, Vandenbon A, Matsushita K, Hernandez-Cuellar E, Kuniyoshi K, Satoh T, Mino T, Suzuki Y, Standley DM,Tsujimura T, Rakugi H, Isaka Y,Takeuchi O, Akira S Malt1-induced cleavage of Regnase-1 in CD4+ helper T cells regulates immune activation Cell Volume 153 Issue 5 1036-1049 2013
• Vandenbon A, Kumagai Y, Teraguchi S, Amada KM, Akira S, Standley DM A Parzen window-based approach for the detection of locally enriched transcription factor binding sites BMC Bioinformatics Volume 14, 26 2013
• Kawasaki T, Takemura N, Standley DM, Akira S,Kawai T The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signalling Cell Host Microbe 14(2) 148-158
• Onishi M, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Coban C, Ishii KJ Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets Vaccine In press In press 2014
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